GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis.

@article{Karbstein2006GTPdependentFO,
  title={GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis.},
  author={Katrin Karbstein and Jennifer A. Doudna},
  journal={Journal of molecular biology},
  year={2006},
  volume={356 2},
  pages={432-43}
}
Ribosome biogenesis in eukaryotic organisms involves the coordinated assembly of 78 ribosomal proteins onto the four ribosomal RNAs, mediated by a host of trans-acting factors whose specific functions remain largely unknown. The essential GTPase Bms1, the putative endonuclease Rcl1 and the essential U3 small nucleolar RNA form a stable subcomplex thought to control an early step in the assembly of the 40S ribosomal subunit. Here, we provide a complete thermodynamic analysis of GTP-dependent… CONTINUE READING
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