GTP-binding-protein-coupled receptor kinases--two mechanistic models.

@article{Palczewski1997GTPbindingproteincoupledRK,
  title={GTP-binding-protein-coupled receptor kinases--two mechanistic models.},
  author={Krzysztof Palczewski},
  journal={European journal of biochemistry},
  year={1997},
  volume={248 2},
  pages={
          261-9
        }
}
Six vertebrate protein kinases (G-protein-coupled receptor kinases; GRKs) that regulate the function of G-protein-coupled receptors (GPCRs) were recently cloned; several distinct properties set them apart from conventional second-messenger regulated protein kinases. It appears that GRKs bind GPCR* through two separate sites: a high-affinity site, which involves intracellular loops of the activated receptor, and the lower-affinity site, encompassing the phosphorylation region. The high-affinity… CONTINUE READING

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