GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796.

@article{McCown2009GT1aOG,
  title={GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796.},
  author={Matthew F. McCown and Sonal Rajyaguru and Simran Kular and Nick Cammack and Isabel N{\'a}jera},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 5},
  pages={2129-32}
}
In vitro, telaprevir selects subtype-specific resistance pathways for hepatitis C virus GT-1a and GT-1b, as described to have occurred in patients. In GT-1a, the HCV-796 resistance mutation C316Y has low replication capacity (7%) that can be compensated for by the emergence of the mutation L392F or M414T, resulting in an increase in replication levels of > or = 10-fold. 
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