GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans.

@article{Kim2010GSTT1AG,
  title={GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans.},
  author={Sang-Heon Kim and Sang-Hoon Kim and Ho Joo Yoon and Dong Ho Shin and Sung Soo Park and Youn-Seup Kim and Jae-Seuk Park and Young Koo Jee},
  journal={Tuberculosis},
  year={2010},
  volume={90 1},
  pages={
          39-43
        }
}
Adverse reactions induced by antituberculosis drugs (ATD) often result in serious morbidities, impeding scheduled treatment and cure. In the development of ATD-induced adverse reactions, glutathione S-transferase has been suggested to play a protective role as an intracellular scavenger by conjugating toxic reactive metabolites of ATD. This study examined the association of null mutations in GST enzyme genes (GSTT1 and GSTM1) with the development of ATD-induced hepatitis and cutaneous reactions… CONTINUE READING

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