GSTP1 promoter hypermethylation is an early event in breast carcinogenesis

@article{Lee2007GSTP1PH,
  title={GSTP1 promoter hypermethylation is an early event in breast carcinogenesis},
  author={Ji Shin Lee},
  journal={Virchows Archiv},
  year={2007},
  volume={450},
  pages={637-642}
}
Promoter hypermethylation in precursor lesions of the breast cancer may be biomarkers of cancer risk and targets for cancer chemoprevention. Pi-class glutathione-S-transferases (GSTP1) is inactivated by promoter hypermethylation in invasive breast cancers. However, little is known about epigenetic silencing of GSTP1 gene by promoter hypermethylation in precursor lesions. To determine the significance of GSTP1 promoter hypermethylation in breast carcinogenesis, methylation status of GSTP1 gene… CONTINUE READING