GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: regulation by promoter methylation and extracellular regulated kinase signaling

@article{Zhang2009GSTP1DC,
  title={GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: regulation by promoter methylation and extracellular regulated kinase signaling},
  author={Ye Zhang and Xiujuan Qu and Wei Jing and Xuejun Hu and Xiang-Hong Yang and Kezuo Hou and Yuee Teng and Jingdong Zhang and Yunpeng Liu},
  journal={Anti-Cancer Drugs},
  year={2009},
  volume={20},
  pages={208-214}
}
Detoxification mechanisms can play a pivotal role in determining tumor cell responses to platinum-based chemotherapy. Glutathione S-transferase-pi (GSTP1) belongs to a supergene family of detoxifying enzymes involved in the prevention of DNA damage and subsequent platinum resistance in numerous cancers. The role of GSTP1 in gastric cancer sensitivity to chemotherapy is, however, not known. In this study, we found that the human gastric cancer cell line MGC803 was significantly more sensitive to… 
View on Wolters Kluwer
or.nsfc.gov.cn
10 Citations
Background Citations
5

10 Citations

Citation Type

Citation Type

Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells.
CLDN6 promotes chemoresistance through GSTP1 in human breast cancer
TLDR
Claudin-6 interacted with p53 and promoted translocation of p53 from nucleus to cytoplasm, and both the expression and enzyme activity of GSTP1 were regulated by p53, providing a new insight into mechanisms and strategies to overcome chemoresistance in breast cancer.
Role of integrin-linked kinase in multi-drug resistance of human gastric carcinoma SGC7901/DDP cells.
TLDR
Roles of expression silencing of ILK in multi-drug resistance reversal of human gastric carcinoma SGC7901/DDP cells, including increased drug sensitivity to cisplatin, cell apoptosis rates, and intracellular accumulation of Rhodamine-123 are focused on.
Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence
TLDR
In vitro whether PTX alone or in combination with CIS induces apoptosis and/or senescence in cervix cancer HeLa and SiHa cell lines infected with HPV types 16 and 18, as well as in immortalized keratinocytyes HaCaT cells is studied.
DNA hypermethylation biomarkers to predict response to cisplatin treatment, radiotherapy or chemoradiation: the present state of art
TLDR
This review summarized the present state of art regarding hypermethylated genes and their affected signaling pathways that are associated with outcome after cisplatin treatment, radiotherapy or chemoradiation in cervical cancer and concluded that a comprehensive screening of a large panel of methylation markers associated with both good as well as poor clinical outcome have to be investigated.
Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line
TLDR
This study is the first discovery of the interaction of RKIP with HSP90, 14-3-3, and keratin, and it is hoped that the present data would provide insight into the molecular mechanisms of how RKip inhibits the occurrence and development of GC.
Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors
TLDR
There was increased expression of some transporters that may play a role in chemotherapy uptake after decitabine administration, and there was a trend towards an inverse correlation between change in SLC19A1 methylation and change in RFC1 expression.
Interaction between GSTP1 Val Allele and H. pylori Infection, Smoking and Alcohol Consumption and Risk of Gastric Cancer among the Chinese Population
TLDR
The GSTP1 Val allele shows an interaction with smoking, alcohol consumption, and especially H. pylori infection for increasing the risk of gastric cancer, and could demonstrate new pathophysiological pathways for the development of Gastric cancer.
Cellular Responses to Cisplatin-Induced DNA Damage
TLDR
This paper summarizes the current understandings regarding the mechanisms by which cisplatin induces cell death and the bases of cis Platin resistance, and discusses various steps, including the entry of cis platin inside cells, DNA repair, drug detoxification, DNA damage response, and regulation of cisPlatin-induced apoptosis by protein kinases.
DNA Methylation and Cancer Diagnosis
TLDR
The main technologies available for the detection and the discovery of aberrantly methylated DNA patterns are described and the different sources of biological samples suitable for DNA methylation studies are presented.

References

SHOWING 1-10 OF 43 REFERENCES
Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.
TLDR
The results suggest that aberrant methylation of GSTP1 may contribute to the carcinogenetic process in breast and renal carcinomas.
Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma.
Glutathione S-transferase pi1 promotes tumorigenicity in HCT116 human colon cancer cells.
TLDR
It is found that disruption of the GSTP1 gene in HCT116 human colorectal cancer cells using targeted homologous recombination resulted in impaired clonogenic survival and proliferation.
Glutathione S-Transferase π1 Promotes Tumorigenicity in HCT116 Human Colon Cancer Cells
TLDR
It is found that disruption of the GSTP1 gene in HCT116 human colorectal cancer cells using targeted homologous recombination resulted in impaired clonogenic survival and proliferation and promoted mitogen-activated protein kinase-extracellular signal-regulated kinase–mediated G1-S cell cycle progression.
Association of GSTP1 expression with resistance to docetaxel and paclitaxel in human breast cancers.
  • T. Arai, Y. Miyoshi, +5 authors S. Noguchi
  • Biology, Medicine
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • 2008
Expression of multidrug resistance-related proteins p-glycoprotein, glutathione-s-transferases, topoisomerase-II and lung resistance protein in primary gastric cardiac adenocarcinoma.
TLDR
This retrospective study included 69 resected specimens from patients with PGCA that received chemotherapy prior to surgery and found the positive rates of expression of PGP, GST-pi, Topo-II and LRP in malignant tissues were all higher than that of the normal tissues.
Expression of Multidrug Resistance-Related Proteins p-Glycoproteinglutathione-s-Transferases, Topoisomerase-II and Lung Resistance Protein in Primary Gastric Cardiac Adenocarcinoma
TLDR
A significant positive correlation was observed between GST-π and lymphatic metastasis and the co-expression of all four tested MDR-related proteins also existed, and a non-statistical increasing trend towards LRP expression status was noted.
Association of GSTP1 CpG Islands Hypermethylation with Poor Prognosis in Human Breast Cancers
TLDR
GSTP1 CpG islands hypermethylation, but not GSTP1 protein expression, is associated with a poor prognosis of breast cancers, suggesting that GSTP 1 C pG islandshypermethylation has a potential to serve as a clinically useful prognostic factor.
Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatment.
Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population
TLDR
XRCC1 genotyping might make tailor chemotherapy possible for gastric cancer patients treated with oxaliplatin-based chemotherapy, and no significant association was found between SNPs of XPD-751, GSTP1-105 and survival.
...
1
2
3
4
5
...