GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer.

@article{Nakayama2004GSTP1CI,
  title={GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer.},
  author={Masashi Nakayama and Mark L. Gonzalgo and Srinivasan Thomas Yegnasubramanian and Xiaohui Lin and Angelo M De Marzo and William Andrew Nelson},
  journal={Journal of cellular biochemistry},
  year={2004},
  volume={91 3},
  pages={540-52}
}
Somatic hypermethylation of CpG island sequences at GSTP1, the gene encoding the pi-class glutathione S-transferase, appears to be characteristic of human prostatic carcinogenesis. To consider the potential utility of this epigenetic alteration as a biomarker for prostate cancer, we present here a comprehensive review of the literature describing somatic GSTP1 changes in DNA from prostate cells and tissues. GSTP1 CpG island hypermethylation has been detected in prostate cancer DNA using a… CONTINUE READING

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