GSTP1, GSTM1, and GSTT1 genetic polymorphisms in patients with cryptogenic liver cirrhosis

@article{MSc2004GSTP1GA,
  title={GSTP1, GSTM1, and GSTT1 genetic polymorphisms in patients with cryptogenic liver cirrhosis},
  author={Shahrokh Mohammadzadeh Ghobadloo M.Sc. and Bahram Yaghmaei and Valery Vladimir Bakayev and Ph.D. Hossein Goudarzi and Babak Noorinayer and Farhad Haghighi Rad M.Sc. and Saeed Samiy and Sohrab Aghabozorghi M.Sc. and Mohammad Reza Zali},
  journal={Journal of Gastrointestinal Surgery},
  year={2004},
  volume={8},
  pages={423-427}
}
We investigated glutathione S-transferase (GST) P1I le (105) Val, T1, and M1 polymorphisms in 45 patients with documented cryptogenic cirrhosis and 56 healthy control subjects. Polymerase chain reaction-based procedures were performed in the studied populations to confirm the genotypes of GSTT1, M1, and P1. Ile/Val and Val/Val GSTP1 genotypes were more frequent in the patients with cirrhosis (n = 39, 87%) than in the control subjects (n = 10; 18%) (odds ratio [OR] 34.04; 95% confidence interval… CONTINUE READING

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