GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: a case-control study.

@article{Matic2013GSTA1GG,
  title={GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: a case-control study.},
  author={Marija G. Matic and Tatjana Pekmezovic and Tatjana Djukic and J I Mimic-oka and Dejan P. Dragicevic and Biljana N. Krivic and Sonja Suvakov and Ana R. Savic-Radojevic and Marija S. Pljesa-Ercegovac and Cane Tuli{\'c} and Vesna M. Coric and Tatjana P. Simic},
  journal={Urologic oncology},
  year={2013},
  volume={31 7},
  pages={1184-92}
}
OBJECTIVES Glutathione S-transferases (GSTs) are a family of enzymes involved in detoxification. Genes encoding for GSTA1, GSTM1, GSTP1, and GSTT1 proteins are polymorphic, which can result in complete or partial loss of enzyme activity. Previous studies have associated polymorphisms of GSTA1, GSTM1, and GSTP1 genes with a higher risk of bladder cancer, but this is still controversial. Potential role of GSTA1 polymorphism in susceptibility to bladder cancer in Whites is lacking. We examined… CONTINUE READING
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