GST M1 polymorphism associates with DNA oxidative damage and mortality among hemodialysis patients.

@article{Lin2009GSTMP,
  title={GST M1 polymorphism associates with DNA oxidative damage and mortality among hemodialysis patients.},
  author={Yi-Sheng Lin and S C Hung and Yau-Huei Wei and Der-Cherng Tarng},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2009},
  volume={20 2},
  pages={405-15}
}
Leukocyte 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a surrogate marker of oxidant-induced DNA damage in patients undergoing maintenance hemodialysis (MHD). Glutathione S-transferase M1 (GST M1) is a member of the GST family of proteins, which protect cellular DNA against oxidative damage. This study tested the association of a common GST M1 gene polymorphism [GST M1(-)], known to produce a dysfunctional enzyme, with levels of 8-OHdG in peripheral blood leukocytes and all-cause mortality among MHD… CONTINUE READING