GSK3b-inhibitor lithium chloride enhances activation of Wnt canonical signaling and osteoblast differentiation on hydrophilic titanium surfaces.

@article{Galli2013GSK3binhibitorLC,
  title={GSK3b-inhibitor lithium chloride enhances activation of Wnt canonical signaling and osteoblast differentiation on hydrophilic titanium surfaces.},
  author={Carlo Galli and Marilina Piemontese and Simone Lumetti and Edoardo Manfredi and Guido Maria Macaluso and Giovanni Passeri},
  journal={Clinical oral implants research},
  year={2013},
  volume={24 8},
  pages={921-7}
}
AIMS Promoting bone formation at the tissue interface is an important step to improve implant success. This study investigated whether stimulation of Wnt signaling by GSK3b inhibitor lithium chloride (LiCl) could affect the response of mesenchymal or osteoblastic cells growing on titanium surfaces with different topography and wettability, and improve their differentiation along the osteoblastic lineage. MATERIAL AND METHODS Murine mesenchymal C2C12 cells were plated on Pickled, acid-etched… CONTINUE READING

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