GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells

@article{Si2011GSK3IE,
  title={GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells},
  author={Jutong Si and L V M{\"u}ller and Steven John Collins},
  journal={Leukemia},
  year={2011},
  volume={25},
  pages={1914-1918}
}
Glycogen synthase kinase3 (GSK3) is an ubiquitously expressed serine threonine kinase originally characterized (and named) as an enzyme, which phosphorylated and inactivated glycogen synthase, an important mediator of glycogen biosynthesis. However, GSK3 has subsequently been shown to phosphorylate a wide range of cellular proteins and to have a central role in multiple cellular functions governing cell metabolism, gene expression, cell division, apoptosis, stem cell maintenance and… CONTINUE READING
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