GSK3 Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

Abstract

Myelin-associated inhibitors (MAIs) contribute to failed regeneration in the CNS. The intracellular signaling pathways through which MAIs block axonal repair remain largely unknown. Here, we report that the kinase GSK3 is directly phosphorylated and inactivated by MAIs, consequently regulating protein–protein interactions that are critical for myelin… (More)

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@inproceedings{Alabed2010GSK3RM, title={GSK3 Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4}, author={Yazan Z. Alabed and Madeline Pool and Stephan Ong Tone and Calum Sutherland and Alyson E Fournier}, year={2010} }