GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity.

@article{Cichocki2017GSK3ID,
  title={GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity.},
  author={Frank M. Cichocki and Bahram Valamehr and Ryan Lee Bjordahl and Bin Zhang and Betsy D Rezner and Paul R. Rogers and Svetlana Gaidarova and Stacey Moreno and Katie Tuininga and Phillip R. Dougherty and Valarie McCullar and Philip Wilson Howard and Dhifaf Sarhan and Emily Taras and Heinrich Schlums and Stewart Abbot and Daniel Shoemaker and Yenan T Bryceson and Bruce R Blazar and Scott Wolchko and Steven D. Cooley and Jeffrey S Miller},
  journal={Cancer research},
  year={2017},
  volume={77 20},
  pages={
          5664-5675
        }
}
Maturation of human natural killer (NK) cells as defined by accumulation of cell-surface expression of CD57 is associated with increased cytotoxic character and TNF and IFNγ production upon target-cell recognition. Notably, multiple studies point to a unique role for CD57+ NK cells in cancer immunosurveillance, yet there is scant information about how they mature. In this study, we show that pharmacologic inhibition of GSK3 kinase in peripheral blood NK cells expanded ex vivo with IL15 greatly… CONTINUE READING
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