GSK3β inhibition and KATP channel opening mediate acute opioid-induced cardioprotection at reperfusion

@article{Gross2007GSK3IA,
  title={GSK3$\beta$ inhibition and KATP channel opening mediate acute opioid-induced cardioprotection at reperfusion},
  author={Eric R. Gross and Anna K. Hsu and Garrett John Gross},
  journal={Basic Research in Cardiology},
  year={2007},
  volume={102},
  pages={341-349}
}
Both glycogen synthase kinase 3β (GSK3β) and the ATP-dependant potassium channel (KATP) mediate opioid-induced cardioprotection (OIC). However, whether direct KATP channel openers induce cardioprotection prior to reperfusion and their signaling cascade position with respect to GSK3β inhibition is unknown. Therefore, we investigated the role of KATP channel opening at reperfusion in OIC, and the interaction between the GSK signaling axis and KATP channels in cardioprotection.Male Sprague-Dawley… 
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