GSK-3 mediates differentiation and activation of proinflammatory dendritic cells.

@article{Rodionova2007GSK3MD,
  title={GSK-3 mediates differentiation and activation of proinflammatory dendritic cells.},
  author={Elena Vitalyevna Rodionova and Michael Conzelmann and Eugene Maraskovsky and Michael M. Hess and Michael Anthony Kirsch and Thomas D. Giese and Anthony D. Ho and M. Bettina Zoeller and Peter Dreger and Thomas Schneider Luft},
  journal={Blood},
  year={2007},
  volume={109 4},
  pages={
          1584-92
        }
}
The key components of the intracellular molecular network required for the expression of a specific function of dendritic cells (DCs) are as yet undefined. Using an in vitro model of human monocyte-derived DC differentiation, this study investigates the role of glycogen synthase kinase 3 (GSK-3), a multifunctional enzyme critical for cellular differentiation, apoptosis, self-renewal, and motility, in this context. We demonstrate that GSK-3 (1) inhibits macrophage development during… CONTINUE READING

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