GSK-3-mediated phosphorylation enhances Maf-transforming activity.

  title={GSK-3-mediated phosphorylation enhances Maf-transforming activity.},
  author={Nathalie Rocques and Nancy Abou Zeid and Karine Sii-Felice and Laure Lecoin and Marie-Paule Felder-Schmittbuhl and Alain Eych{\`e}ne and Celio Pouponnot},
  journal={Molecular cell},
  volume={28 4},
The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-transforming activity is controlled by GSK-3-dependent phosphorylation and that phosphorylation by GSK-3 can increase the oncogenic activity of a protein. Using microarray analysis, we identify a gene-expression subprogram regulated by GSK-3-mediated… CONTINUE READING
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