GSK-3β inhibition attenuates LPS-induced death but aggravates radiation-induced death via down-regulation of IL-6.


BACKGROUND Exposure of high dose ionizing radiation is lethal. Signal pathways involved in radiation biology reaction still remain illdefined. Lipopolysaccharides (LPS), the ligands of Toll-like receptor 4(TLR4), could elicit strong immune responses. Glycogen synthase kinase-3β(GSK-3β) promotes the production of inflammatory molecules and cell migration… (More)
DOI: 10.1159/000356606