GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

  title={GSK-3α regulates production of Alzheimer's disease amyloid-β peptides},
  author={Christopher J Phiel and Christina A. Wilson and Virginia M. Y. Lee and Peter G. Klein},
Alzheimer's disease is associated with increased production and aggregation of amyloid-β (Aβ) peptides. Aβ peptides are derived from the amyloid precursor protein (APP) by sequential proteolysis, catalysed by the aspartyl protease BACE, followed by presenilin-dependent γ-secretase cleavage. Presenilin interacts with nicastrin, APH-1 and PEN-2 (ref. 6), all of which are required for γ-secretase function. Presenilins also interact with α-catenin, β-catenin and glycogen synthase kinase-3β (GSK-3… CONTINUE READING
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