GSK-3α/β kinases and amyloid production in vivo

  title={GSK-3α/β kinases and amyloid production in vivo},
  author={Tomasz Jaworski and Ilse Dewachter and Benoit Lechat and Maarten Gees and Anna M Kremer and David Demedts and Peter Borghgraef and Herman Devijver and Seb K{\"u}gler and Satish Patel and James R Woodgett and F. Van Leuven},
Arising from C. J. Phiel, C. A. Wilson, V. M.-Y. Lee & P. S. Klein 423, 435–439 (2003)10.1038/nature01640A major unresolved issue in Alzheimer’s disease is identifying the mechanisms that regulate proteolytic processing of amyloid precursor protein (APP)—glycogen synthase kinase-3 (GSK-3) isozymes are thought to be important in this regulation. Phiel et al. proposed that GSK-3α, but not GSK-3β, controls production of amyloid. We analysed the proteolytic processing of mouse and human APP in… CONTINUE READING
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