GSH extrusion and and the mitochondrial pathway of apoptotic signalling.

@article{Coppola2000GSHEA,
  title={GSH extrusion and and the mitochondrial pathway of apoptotic signalling.},
  author={Simona Coppola and Lina Ghibelli},
  journal={Biochemical Society transactions},
  year={2000},
  volume={28 2},
  pages={56-61}
}
New evidence suggests that physiological and damaging agents activate two different pathways of apoptotic signalling, which are mediated by protein-protein interactions and mitochondrial alterations respectively. The two pathways converge at the activation of caspase 3, the key effector of the execution phase of apoptosis, thus giving similar final results. The knowledge that different biochemical routes exist allows us to re-evaluate previous apparently contradictory results concerning the… CONTINUE READING