GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.

@article{Kang2012GSDMBORMDL3VC,
  title={GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.},
  author={Mi-jin Kang and Ho-Sung Yu and Ju-Hee Seo and Hyung Young Kim and Young-Ho Jung and Young-Joon Kim and Ha-Jung Kim and So Yeon Lee and Soo Jong Hong},
  journal={Human immunology},
  year={2012},
  volume={73 9},
  pages={954-9}
}
In 2007, a genome-wide association study identified associations between variants involved in the regulation of ORMDL3 expression and asthma. These observations were subsequently replicated in case-control studies in several ethnic groups. We investigated the possible contribution of GSDMB/ORMDL3 variants to asthma susceptibility and intermediate asthma phenotypes in Korean children. The polymorphisms rs7216389, rs4794820, rs4065275, and rs11650680 were genotyped using the TaqMan assay in 931… CONTINUE READING