GS domain mutations that constitutively activate T beta R‐I, the downstream signaling component in the TGF‐beta receptor complex.

@article{Wieser1995GSDM,
  title={GS domain mutations that constitutively activate T beta R‐I, the downstream signaling component in the TGF‐beta receptor complex.},
  author={R. Wieser and J. Wrana and J. Massagu{\'e}},
  journal={The EMBO Journal},
  year={1995},
  volume={14}
}
The TGF‐beta type II receptor (T beta R‐II) is a transmembrane serine/threonine kinase that, upon ligand binding, recruits and phosphorylates a second transmembrane kinase, T beta R‐I, as a requirement for signal transduction. T beta R‐I is phosphorylated by T beta R‐II in the GS domain, a 30 amino acid region preceding the kinase domain and conserved in type I receptors for other TGF‐beta‐related factors. The functional role of seven serines and threonines in the T beta R‐I GS domain was… Expand
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