GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

  title={GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses},
  author={Michael K Lo and Robert W. Jordan and Aaron Arvey and Jawahar Sudhamsu and Punya Shrivastava-Ranjan and Anne L. Hotard and Mike Flint and L K McMullan and Dustin Siegel and Michael O Clarke and Richard L. Mackman and Hon C. Hui and Michel Perron and Adrian S Ray and Tom{\'a}{\vs} Cihl{\'a}ř and Stuart T Nichol and Christina F Spiropoulou},
  booktitle={Scientific reports},
GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new… CONTINUE READING
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