GRbeta expression in nasal polyp inflammatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone.

@article{Hamilos2001GRbetaEI,
  title={GRbeta expression in nasal polyp inflammatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone.},
  author={Daniel L. Hamilos and Donald Y. M. Leung and Shigeo Muro and Andrew M. Kahn and S S Hamilos and Stanley E. Thawley and Qutayba A. Hamid},
  journal={The Journal of allergy and clinical immunology},
  year={2001},
  volume={108 1},
  pages={59-68}
}
BACKGROUND Nasal polyposis disease is an inflammatory disorder with intense eosinophilic infiltration of respiratory mucosa that is often difficult to control with topical steroids. Recent evidence suggests that overexpression of the glucocorticoid receptor splice variant GRbeta in inflammatory cells might contribute to steroid insensitivity in diseases such as asthma. OBJECTIVE The purposes of this investigation were to determine whether nasal polyp (NP) inflammatory cells overexpress GRbeta… CONTINUE READING