GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells.

@article{Ohhashi2006GRP78bindingPR,
  title={GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells.},
  author={Kentaro Oh-hashi and Yoko Hirata and Hisashi Koga and Kazutoshi Kiuchi},
  journal={FEBS letters},
  year={2006},
  volume={580 16},
  pages={3943-7}
}
We previously reported that a novel GRP78-binding protein (GBP) is predominantly expressed in rat brain and its expression declines through the aging process. To characterize its biological function, we established C6 glioblastoma cells that stably overexpressed GBP. Stable overexpression of GBP attenuated cAMP-induced expression of the glial fibrillary acidic protein (GFAP) gene, which was accompanied by a decrease in cAMP-induced signal transducer and activators of transcription 3 (STAT3… CONTINUE READING