GRP78 Knockdown Enhances Apoptosis via the Down-Regulation of Oxidative Stress and Akt Pathway after Epirubicin Treatment in Colon Cancer DLD-1 Cells

Abstract

INTRODUCTION The 78-kDa glucose-regulated protein (GRP78) is induced in the cancer microenvironment and can be considered as a novel predictor of responsiveness to chemotherapy in many cancers. In this study, we found that intracellular reactive oxygen species (ROS) and nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation were higher in… (More)
DOI: 10.1371/journal.pone.0035123

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@inproceedings{Chang2012GRP78KE, title={GRP78 Knockdown Enhances Apoptosis via the Down-Regulation of Oxidative Stress and Akt Pathway after Epirubicin Treatment in Colon Cancer DLD-1 Cells}, author={Yu-Jia Chang and Yi-Ping Huang and Zih-Ling Li and Ching-Hsein Chen}, booktitle={PloS one}, year={2012} }