GRP78: a multifunctional receptor on the cell surface.

  title={GRP78: a multifunctional receptor on the cell surface.},
  author={Mario Gonzalez-Gronow and Maria Angelica Selim and John A Papalas and Salvatore Vincent Pizzo},
  journal={Antioxidants & redox signaling},
  volume={11 9},
The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum chaperone, whose function is generally thought to be restricted to controlling the structural maturation of nascent glycoproteins. However, GRP78 also is expressed on the cell surface where it functions as a receptor for a wide variety of ligands, behaving as an autoantigen for several classes of autoantibodies. GRP78 is a signaling receptor for activated alpha2-macroglobulin, plasminogen kringle 5, and microplasminogen… CONTINUE READING


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