GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.

@article{Luo2006GRP78BiPIR,
  title={GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.},
  author={Shengzhan Luo and Changhui Mao and Brenda Lee and Amy Si-Ying Lee},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 15},
  pages={5688-97}
}
GRP78, also known as BiP, is a central regulator of endoplasmic reticulum (ER) homeostasis due to its multiple functional roles in protein folding, ER calcium binding, and controlling of the activation of transmembrane ER stress sensors. ER stress induction of GRP78/BiP represents a major prosurvival arm of the unfolded protein response (UPR). However, the physiological role of GRP78 in development is not known. Using a transgenic approach, we discovered that the Grp78 promoter is activated in… CONTINUE READING
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