GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.

@article{JasiskaMyga2009GRN3C,
  title={GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.},
  author={Barbara Jasińska-Myga and Christian Wider and Grzegorz M Opala and Anna Krygowska-Wajs and Maria Barcikowska and Krzysztof Czyżewski and Matt Baker and Rosa Rademakers and Ryan J. Uitti and Matthew John Farrer and Owen A. Ross and Zbigniew K Wszolek},
  journal={European journal of neurology},
  year={2009},
  volume={16 8},
  pages={909-11}
}
BACKGROUND AND PURPOSE A single nucleotide polymorphism in the 3'-untranslated region of the progranulin gene (GRN; 3'UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. METHODS As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian… CONTINUE READING