GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.

@article{Cheng2010GRK5DA,
  title={GRK5 deficiency accelerates \{beta\}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.},
  author={Shaowu Cheng and Longxuan Li and Shuangteng He and Jun Yong Liu and Yuning Sun and Minchao He and Kenneth A. Grasing and Richard T Premont and William Z. Suo},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 53},
  pages={41541-8}
}
Membrane G protein-coupled receptor kinase 5 (GRK5) deficiency is linked to Alzheimer disease, yet its precise roles in the disease pathogenesis remain to be delineated. We have previously demonstrated that GRK5 deficiency selectively impairs desensitization of presynaptic M2 autoreceptors, which causes presynaptic M2 hyperactivity and inhibits acetylcholine release. Here we report that inactivation of one copy of Grk5 gene in transgenic mice overexpressing β-amyloid precursor protein (APP… CONTINUE READING
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