GRK5 Is Associated with the Regulation of Methadone Dosage in Heroin Dependence

@inproceedings{Wang2018GRK5I,
  title={
GRK5 Is Associated with the Regulation of Methadone Dosage in Heroin Dependence},
  author={Sheng-Chang Wang and Ren-Hua Chung and Hsiang-Wei Kuo and Tung-Hsia Liu and Chiu-Ping Fang and Shu Chih Liu and Chia-Chen Liu and Hsiao-Hui Tsou and Andrew H. Chen and Yu-Li Liu},
  booktitle={The international journal of neuropsychopharmacology},
  year={2018}
}
Background There is no countable biomarker for opioid dependence treatment responses thus far. In this study, we recruited Taiwanese methadone maintenance treatment patients to search for genes involving the regulatory mechanisms of methadone dose by genome-wide association analyses. Methods A total of 344 Taiwanese methadone maintenance treatment patients were included in a genome-wide association study. The involvement of GRK5 in opioid dependence was then further confirmed by gene… CONTINUE READING
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