GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson’s disease via its RGS homology domain

@inproceedings{Ahmed2015GRK3SL,
  title={GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson’s disease via its RGS homology domain},
  author={Mohamed Rafiuddin Ahmed and Evgeny Bychkov and Lingyong Li and Vsevolod V. Gurevich and Eugenia V Gurevich},
  booktitle={Scientific reports},
  year={2015}
}
Degeneration of dopaminergic neurons causes Parkinson's disease. Dopamine replacement therapy with L-DOPA is the best available treatment. However, patients develop L-DOPA-induced dyskinesia (LID). In the hemiparkinsonian rat, chronic L-DOPA increases rotations and abnormal involuntary movements modeling LID, via supersensitive dopamine receptors. Dopamine receptors are controlled by G protein-coupled receptor kinases (GRKs). Here we demonstrate that LID is attenuated by overexpression of GRK3… CONTINUE READING
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