GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.

Lin Piao, Yong-Hu Fang, +9 authors Stephen Lawrence Archer
Published 2012 in Circulation

Abstract

BACKGROUND The cause and consequences of impaired adrenergic signaling in right ventricular failure/hypertrophy (RVH) are poorly understood. We hypothesized that G protein-coupled receptor kinase-2 (GRK2)-mediated uncoupling of β-adrenergic receptor signaling impairs inotropic reserve. The implications of right ventricular (RV) adrenergic remodeling for… (More)

DOI: 10.1161/CIRCULATIONAHA.112.109868

Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.

Dalia Urboniene, Idith Haber, Yong-Hu Fang, Thenappan Thenappan, Stephen L Archer
American journal of physiology. Lung cellular and…
2010

GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.

Abstract

Topics

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Cited By

Right ventricular failure due to chronic pressure load: What have we learned in animal models since the NIH working group statement?

The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy

Alpha2-adrenoceptors in adrenomedullary chromaffin cells: functional role and pathophysiological implications

G Protein-Coupled Receptor-G-Protein βγ-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure.

Regulatory effects of GRK2 on GPCRs and non-GPCRs and possible use as a drug target (Review).

Right ventricular relative wall thickness as a predictor of outcomes and of right ventricular reverse remodeling for patients with pulmonary hypertension

Risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis

Current Challenges in Pediatric Heart Failure and Transplantation

Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension: Part II: Neurohormonal Signaling Contributes to the Pulmonary Vascular and Right Ventricular Pathophenotype of Pulmonary Arterial Hypertension.

Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension.

References

G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts.

Outcomes of hospitalisation for right heart failure in pulmonary arterial hypertension.

The physiology, signaling, and pharmacology of dopamine receptors.

α1-adrenoceptor activation induces phosphorylation of β2-adrenoceptors in human prostate tissue.

Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure.

Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.

Adult congenital heart disease importance of the right ventricle.

Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.

Dopamine receptor subtypes in the native human heart

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

Slides referencing similar topics

GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.

Abstract

Topics

Figures and Tables

Cited By

Right ventricular failure due to chronic pressure load: What have we learned in animal models since the NIH working group statement?

The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy

Alpha2-adrenoceptors in adrenomedullary chromaffin cells: functional role and pathophysiological implications

G Protein-Coupled Receptor-G-Protein βγ-Subunit Signaling Mediates Renal Dysfunction and Fibrosis in Heart Failure.

Regulatory effects of GRK2 on GPCRs and non-GPCRs and possible use as a drug target (Review).

Right ventricular relative wall thickness as a predictor of outcomes and of right ventricular reverse remodeling for patients with pulmonary hypertension

Risk factors for pulmonary hypertension in patients receiving maintenance peritoneal dialysis

Current Challenges in Pediatric Heart Failure and Transplantation

Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension: Part II: Neurohormonal Signaling Contributes to the Pulmonary Vascular and Right Ventricular Pathophenotype of Pulmonary Arterial Hypertension.

Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension.

References

G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts.

Outcomes of hospitalisation for right heart failure in pulmonary arterial hypertension.

The physiology, signaling, and pharmacology of dopamine receptors.

α1-adrenoceptor activation induces phosphorylation of β2-adrenoceptors in human prostate tissue.

Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure.

Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.

Adult congenital heart disease importance of the right ventricle.

Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.

Dopamine receptor subtypes in the native human heart

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

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