GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels.

@article{Sato2015GRK2CC,
  title={GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels.},
  author={Priscila Y Sato and J. Kurt Chuprun and Jessica Ibetti and Alessandro Cannavo and Konstantinos Drosatos and John W. Elrod and Walter J Koch},
  journal={Journal of molecular and cellular cardiology},
  year={2015},
  volume={89 Pt B},
  pages={360-4}
}
The G protein-coupled receptor kinase-2 (GRK2) is upregulated in the injured heart and contributes to heart failure pathogenesis. GRK2 was recently shown to associate with mitochondria but its functional impact in myocytes due to this localization is unclear. This study was undertaken to determine the effect of elevated GRK2 on mitochondrial respiration in cardiomyocytes. Sub-fractionation of purified cardiac mitochondria revealed that basally GRK2 is found in multiple compartments… CONTINUE READING
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