GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility

@inproceedings{Salazar2013GRK2BW,
  title={GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility},
  author={Norma C Salazar and Ximena Vallejos and Ashley Siryk and Giuseppe Rengo and Alessandro Cannavo and Daniela Liccardo and Claudio de Lucia and Erhe Gao and Dario Leosco and Walter J. Koch and Anastasios Lymperopoulos},
  booktitle={Cell Communication and Signaling},
  year={2013}
}
Backgroundβ1- and β2–adrenergic receptors (ARs) play distinct roles in the heart, e.g. β1AR is pro-contractile and pro-apoptotic but β2AR anti-apoptotic and only weakly pro-contractile. G protein coupled receptor kinase (GRK)-2 desensitizes and opposes βAR pro-contractile signaling by phosphorylating the receptor and inducing beta-arrestin (βarr) binding. We posited herein that GRK2 blockade might enhance the pro-contractile signaling of the β2AR subtype in the heart. We tested the effects of… CONTINUE READING

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