GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression.

Abstract

Transcriptional regulators such as the glucocorticoid receptor (GR) recruit multiple cofactors to activate or repress transcription. Although most cofactors are intrinsically bifunctional, little is known about the molecular mechanisms dictating the specific polarity of regulation. Furthermore, chromatin modifications thought to be confined to silent loci… (More)
DOI: 10.1073/pnas.0810863105

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