GRIN1 regulates micro-opioid receptor activities by tethering the receptor and G protein in the lipid raft.

@article{Ge2009GRIN1RM,
  title={GRIN1 regulates micro-opioid receptor activities by tethering the receptor and G protein in the lipid raft.},
  author={Xin Lan Ge and Yu Qiu and Horace H. Loh and Ping-Yee Law},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 52},
  pages={
          36521-34
        }
}
The lipid raft location of mu-opioid receptor (MOR) determines the receptor activities. However, the manner in which MOR is anchored within the lipid rafts is undetermined. Using the targeted proteomic approach and mass spectrometry analyses, we have identified GRIN1 (G protein-regulated inducer of neurite outgrowth 1) can tether MOR with the G protein alpha-subunit and subsequently regulate the receptor distribution within the lipid rafts. Glutathione S-transferase fusion pulldown and receptor… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS