GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.

Abstract

Epithelial-mesenchymal transition (EMT), a biological process by which polarized epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to the molecular heterogeneity of epithelial ovarian cancer (EOC). Here we report that a transcription factor--Grainyhead-like 2 (GRHL2) maintains the epithelial phenotype. EOC tumours with… (More)
DOI: 10.1038/srep19943

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Cite this paper

@article{Chung2016GRHL2miR200ZEB1MT, title={GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.}, author={Vin Yee Chung and Tuan Zea Tan and Ming Tan and Meng K Wong and Kuee Theng Kuay and Zhe Yang and Jieru Ye and J. J. A. Muller and Cheryl Koh and Ernesto Guccione and Jean Paul Thiery and Ruby Yun-Ju Huang}, journal={Scientific reports}, year={2016}, volume={6}, pages={19943} }