GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli

@inproceedings{Wang2019GREACEassistedAL,
  title={GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli},
  author={Xiaowei Wang and Qinggang Li and Cunmin Sun and Zhen Cai and Xiaomei Zheng and Xuan Guo and Xiaomeng Ni and Wenjuan Zhou and Yanmei Guo and Ping Zheng and Ning Chen and Jibin Sun and Yin Li and Yanhe Ma},
  booktitle={Microbial Cell Factories},
  year={2019}
}
BackgroundLate-stage fermentation broth contains high concentrations of target chemicals. Additionally, it contains various cellular metabolites which have leaked from lysed cells, which would exert multifactorial stress to industrial hyperproducers and perturb both cellular metabolism and product formation. Although adaptive laboratory evolution (ALE) has been wildly used to improve stress tolerance of microbial cell factories, single-factor stress condition (i.e. target product or sodium… CONTINUE READING
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