GRADE guidelines: 2. Framing the question and deciding on important outcomes.

@article{Guyatt2011GRADEG2,
  title={GRADE guidelines: 2. Framing the question and deciding on important outcomes.},
  author={Gordon H. Guyatt and Andrew D. Oxman and Regina Kunz and David Atkins and Jan L. Brożek and Gunn Elisabeth Vist and Philip Alderson and Paul Glasziou and Yngve Falck-Ytter and Holger J. Sch{\"u}nemann},
  journal={Journal of clinical epidemiology},
  year={2011},
  volume={64 4},
  pages={395-400}
}
GRADE requires a clear specification of the relevant setting, population, intervention, and comparator. It also requires specification of all important outcomes--whether evidence from research studies is, or is not, available. For a particular management question, the population, intervention, and outcome should be sufficiently similar across studies that a similar magnitude of effect is plausible. Guideline developers should specify the relative importance of the outcomes before gathering the… CONTINUE READING

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