GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine.

Abstract

The present study evaluates immunogenicity and protection potency of a codon-optimized GRA1 DNA vaccine, wild type GRA1 DNA vaccine and an adjuvanted recombinant GRA1 protein vaccine candidate in BALB/c mice against lethal toxoplasmosis. Of the three GRA1 vaccines tested, the recombinant GRA1 protein vaccine results reveal significant increase in immune response and prolonged survival against acute toxoplasmosis compared to DNA vaccinations. Immune response and protection conferred by codon-optimized GRA1 DNA vaccine was slightly better than wild type GRA1 DNA vaccine.

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@article{Dkaya2007GRA1PV, title={GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine.}, author={Mert D{\"{o}şkaya and Mina Kalantari-Dehaghi and Craig Michael Walsh and Elżbieta Hiszczyńska-Sawicka and D. Huw Davies and Philip L. Felgner and Liza S. Z. Larsen and Richard H. Lathrop and G. Wesley Hatfield and Jessica R Schulz and Y{\"{u}ksel G{\"{u}r{\"{u}z and Frances A Jurnak}, journal={Vaccine}, year={2007}, volume={25 10}, pages={1824-37} }