GR-regulating Serine/Threonine Kinases: New Physiologic and Pathologic Implications

  title={GR-regulating Serine/Threonine Kinases: New Physiologic and Pathologic Implications},
  author={Tomoshige Kino},
  journal={Trends in Endocrinology & Metabolism},
Glucocorticoid hormones, end products of the hypothalamic-pituitary-adrenal axis, virtually influence all human functions both in a basal homeostatic condition and under stress. The glucocorticoid receptor (GR), a nuclear hormone receptor superfamily protein, mediates these actions of glucocorticoids by acting as a ligand-dependent transcription factor. Because glucocorticoid actions are diverse and strong, many biological pathways adjust them in local tissues by targeting the GR signaling… CONTINUE READING


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