GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex.

@article{Li2001GPx1GD,
  title={GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex.},
  author={Qiang Li and Salih Sanlioğlu and Shu Nong Li and Tim Ritchie and Larry W. Oberley and John F. Engelhardt},
  journal={Antioxidants & redox signaling},
  year={2001},
  volume={3 3},
  pages={415-32}
}
Numerous environmental stimuli alter cell functions by the induction of intracellular reactive oxygen species, such as superoxide and hydrogen peroxide (H2O2). These redox alterations can change the activity of kinases and phosphatases responsible for controlling intracellular signal transduction cascades important in determining how cells react to their environment. One such well known pathway includes nuclear factor-kappaB (NFkappaB); however, the exact redox-sensitive factors important in… CONTINUE READING