GPi firing rate modification during beginning-of-dose motor deterioration following acute administration of apomorphine.

@article{Merello1999GPiFR,
  title={GPi firing rate modification during beginning-of-dose motor deterioration following acute administration of apomorphine.},
  author={Marcelo Merello and Andrew John Lees and Jorge Balej and Angel Cammarota and Ram{\'o}n C. Leiguarda},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1999},
  volume={14 3},
  pages={
          481-3
        }
}
  • Marcelo Merello, Andrew John Lees, +2 authors Ramón C. Leiguarda
  • Published in
    Movement disorders : official…
    1999
  • Psychology, Medicine
  • We present a patient with clinically evident beginning-of-dose motor deterioration who had undergone posteroventral pallidotomy. This patient underwent an intrasurgical apomorphine test followed by single cell recording of the internal globus pallidus (GPi) to determine changes in GPi firing rate during the occurrence of such phenomenon. A significant increase in GPi firing rate coincident with worsening of patient disabilities prior to improvement was found. This finding suggests that… CONTINUE READING

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