GPX3 promoter is methylated in chronic myeloid leukemia.

  title={GPX3 promoter is methylated in chronic myeloid leukemia.},
  author={Dong-ming Yao and Jing-Dong Zhou and Ying-Ying Zhang and Lei Yang and Xiang-mei Wen and Jing Yang and Hong Guo and Qin Chen and Jiang Lin and Jun Qian},
  journal={International journal of clinical and experimental pathology},
  volume={8 6},
Hypermethylation of GPX3 (glutathione peroxidase 3) promoter has been identified in various cancers. However, the pattern of GPX3 promoter methylation in chronic myeloid leukemia (CML) remains unknown. Our study was aimed to investigate the methylation status of GPX3 promoter and its clinical relevance in CML. Real-time quantitative methylation-specific PCR and bisulfite sequencing PCR was performed to detect the level of GPX3 methylation in 80 CML patients and 44 controls. GPX3 promoter in CML… CONTINUE READING