GPVI and integrin αIIbβ3 signaling in platelets

@article{Watson2005GPVIAI,
  title={GPVI and integrin $\alpha$IIb$\beta$3 signaling in platelets},
  author={Steve P. Watson and Jocelyn M. Auger and Owen J T McCarty and Andrew C Pearce},
  journal={Journal of Thrombosis and Haemostasis},
  year={2005},
  volume={3}
}
Summary.  This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin αIIbβ3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase‐based signaling cascades leading to activation of phospholipase C γ2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates… 
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380 Citations
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380 Citations

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GPVI and CLEC-2
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References

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TLDR
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TLDR
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TLDR
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TLDR
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The interaction of fibrinogen with the integrin alphaIIbbeta3 plays a crucial role in platelet adhesion and platelet activation leading to the generation of intracellular signals that nucleate the…
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TLDR
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