GPRC6A Null Mice Exhibit Osteopenia, Feminization and Metabolic Syndrome

  title={GPRC6A Null Mice Exhibit Osteopenia, Feminization and Metabolic Syndrome},
  author={Min Pi and Ling Chen and Min-Zhao Huang and Wenyu Zhu and Brian Ringhofer and Junming Luo and Lane Christenson and Benyi Li and Jianghong Zhang and Pamela D Jackson and Pieter Faber and Kurt R. Brunden and John J. Harrington and Leigh Quarles},
  journal={PLoS ONE},
  pages={37 - 46}
BACKGROUND GPRC6A is a widely expressed orphan G-protein coupled receptor that senses extracellular amino acids, osteocalcin and divalent cations in vitro. The physiological functions of GPRC6A are unknown. METHODS/PRINCIPAL FINDINGS In this study, we created and characterized the phenotype of GPRC6A(-/-) mice. We observed complex metabolic abnormalities in GPRC6A(-/-) mice involving multiple organ systems that express GPRC6A, including bone, kidney, testes, and liver. GPRC6A(-/-) mice… CONTINUE READING


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