GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils

@article{Balenga2011GPR55RC,
  title={GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils},
  author={Nariman A. B. Balenga and Elma Aflaki and Julia K Kargl and Wolfgang Platzer and Ralf Schr{\"o}der and Stefanie Bl{\"a}ttermann and Evi Kostenis and Andrew J Brown and Akos Heinemann and Maria Waldhoer},
  journal={Cell Research},
  year={2011},
  volume={21},
  pages={1452-1469}
}
The directional migration of neutrophils towards inflammatory mediators, such as chemokines and cannabinoids, occurs via the activation of seven transmembrane G protein coupled receptors (7TM/GPCRs) and is a highly organized process. A crucial role for controlling neutrophil migration has been ascribed to the cannabinoid CB2 receptor (CB2R), but additional modulatory sites distinct from CB2R have recently been suggested to impact CB2R-mediated effector functions in neutrophils. Here, we provide… CONTINUE READING