GPR48 regulates epithelial cell proliferation and migration by activating EGFR during eyelid development.

Abstract

PURPOSE Eyelid development is a dynamic process involving cell proliferation, differentiation, and migration regulated by a number of growth factors and cytokines. Mice deficient in the orphan G protein-coupled receptor 48 (GPR48) showed an eye open at birth (EOB) phenotype. In this study, the authors attempted to clarify the role of GPR48 in eyelid… (More)
DOI: 10.1167/iovs.08-1860

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